Frenos2.5mg+60mg
Type:Tablet
Generic Name:Pseudoephedrine + Triprolidine
Manufacturer:Opsonin Pharma Limited
Price:৳3.25
Indication
Pneumonia, Pharyngitis, Allergic rhinitis, Upper respiratory tract, Dry cough, Tracheolaryngitis
Adult Dose
Oral Allergic rhinitis, Cold and flu Adult: Each tablet contains triprolidine HCl 2.5 mg and pseudoephedrine HCl 60 mg: 1 tablet 4-6 hrly, up to 4 times a day.
Child Dose
Oral Allergic rhinitis, Cold and flu Child > 12 yr: 1 tablet 4-6 hrly, up to 4 times a day.
Contraindication
Concurrent use or within 2 wk of stopping MAOIs. Severe hypertension or coronary artery disease.
Mode of Action
Triprolidine hydrochloride is a potent competitive histamine H1-receptor antagonist with antimuscarinic and mild sedative properties. Pseudoephedrine, an alpha- and beta-adrenergic receptor agonist, mediates vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa.
Precaution
Severe hepatic impairment. Moderate to severe renal impairment. DM, hyperthyroidism, increased intraocular pressure, prostatic hypertrophy, hypertension, heart disease. May affect ability to drive or operate machinery. Pregnancy and lactation.
Side Effect
Dry mouth, nose and throat; skin rashes, tachycardia, drowsiness, sleep disturbances, urinary retention. Rarely, hallucinations.
Interaction
Increased BP with other sympathomimetic agents (e.g. decongestants, TCA, appetite suppressants). Reduced hypotensive effects of methyldopa, ?- and ?-adrenergic blockers. Increased side effects (e.g. somnolence, agitation) with atomoxetine. Potentially Fatal: Increased risk of hypertensive crisis with furazolidine, avoid concurrent use. Increased risk of hypertensive crisis with MAOIs; avoid concurrent use or within 2 wk after stopping MAOIs. Increased risk of psychosis with bromocriptine.