Sinacet
Type:60ml bot
Generic Name:Levocetrizine Dihydrochloride 0.1%
Manufacturer:The Ibn Sina Pharmaceutical Ind. Ltd.
Price:৳50.00
Indication
Allergic rhinitis, Chronic idiopathic urticaria
Administration
May be taken with or without food.
Adult Dose
Oral Seasonal allergic rhinitis, Chronic idiopathic urticaria Adult: 5mg once daily
Child Dose
Oral Seasonal allergic rhinitis, Chronic idiopathic urticaria Children 12 years of age and older: 5mg once daily Children 6 to 11 years of age: 2.5mg (1/2 tablet or 1 teaspoon oral solution) once daily Children 6 months to 5 years of age: 1.25 mg (1/2 teaspoon oral solution) once daily
Renal Dose
>12 years CrCl: 50-80 mL/min: 2.5 mg PO qDay CrCl: 30-50 mL/min: 2.5 PO qODay CrCl: 10-30 mL/min: 2.5 mg every 3-4 days CrCl: <10 mL/min, hemodialysis: Contraindicated
Contraindication
Lactation. End-stage renal disease (CrCl <10 ml/min) or haemodialysis patients. Child 6-11 yr with renal impairment.
Mode of Action
Levocetirizine is an active isomer of cetirizine which selectively competes w/ histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and resp tract.
Precaution
Renal impairment. May impair ability to drive or operate machinery. Lactation: expected to be excreted in breast milk, avoid
Side Effect
1-10% Dry mouth,Fatigue,Nasopharyngitis,Pharyngitis Frequency Not Defined Somnolence, dizziness, pyrexia, cough, epistaxis, diarrhoea, vomiting, constipation, otitis media, dysuria, urinary retention, blurred vision, angioedema, paraesthesia, dystonia, oculogyric crisis, myoclonus, extrapyramidal symptoms.
Interaction
Possible additive adverse CNS effects w/ CNS depressants (e.g. sedatives, tranquilizers).
