Dutamax500mcg
Type:7 Capsules
Generic Name:Dutasteride
Manufacturer:Drug International Ltd.
Price:৳84.28
Indication
Benign prostatic hyperplasia (BPH)
Administration
May be taken with or without food.
Adult Dose
Oral Benign prostatic hyperplasia Adult: 500 mcg once daily for at least 6 mth. Hepatic impairment: Severe: Contraindicated.
Renal Dose
Renal impairment: Dose adjustment not necessary
Contraindication
Severe liver impairment; pregnant women, children, adolescent.
Mode of Action
Dutasteride has antiandrogenic properties. It inhibits 5alpha-reductase, thus preventing the conversion of testosterone to 5?-dihydrotestosterone which is the main androgen involved in causing prostate enlargement.
Precaution
Excreted in semen therefore use of condom is recommended. Women of childbearing potential should avoid handling dutasteride capsules. Advisable to exclude other causes of benign prostatic hypertrophy (e.g. prostate cancer, infection) before initiating therapy. Lactation: Excretion in milk unknown/contraindicated
Side Effect
1-10% Impotence,Decreased libido,Ejaculation disorder,Breast disorders/gynecomastia <1% Dizziness Frequency Not Defined Cardiac failure,Prostate cancer (high grade)
Pregnancy Category Note
Pregnancy category: X Lactation: Excretion in milk unknown/contraindicated
Interaction
Plasma concentrations may be increased when used concomitantly w/ moderate or potent CYP3A4 inhibitors.
