Ticoplan 400400mg/vial
Type:3ml Vial
Generic Name:Teicoplanin
Manufacturer:Healthcare Pharmaceuticals Ltd.
Price:৳1300.00
Indication
Gram-positive infection, CAPD-associated peritonitis
Adult Dose
Parenteral Severe Gram-positive infections Adult: Initially, 6 mg/kg on first day, followed by 3 mg/kg/day. Severe infection: 6 mg/kg every 12 hr for the 1st 3 doses followed by 6 mg/kg/day. Doses may be given via IM inj, IV bolus or IV infusion over 30 minutes. Intravenous Prophylaxis of Gram-positive infection in high-risk patients undergoing surgery Adult: 400 mg as single dose at induction of anesth. Continuous ambulatory peritoneal dialysis (CAPD)-associated peritonitis Adult: If the patient is febrile, an initial loading dose of 400 mg may be given. Teicoplanin is added to the dialysis solution at a concentration of 20 mg/litre; dose is added into each bag of solution in the first wk, followed by alternate bags in the second wk and then in the overnight dwell bag in the third wk.
Child Dose
Parenteral Severe Gram-positive infections Child: Loading dose: 10 mg/kg every 12 hr for 3 doses followed by 6-10 mg/kg/day depending on severity of the infection. Neonates: Loading dose: 16 mg/kg on the 1st day, followed by maintenance doses of 8 mg/kg/day by IV infusion.
Renal Dose
Parenteral Renal impairment: Usual dose to be given for first 3 days, thereafter adjust dose according to CrCl. CrCl (ml/min) Dosage Recommendation 40-60 1/2 initial dose given daily or initial dose every 2 days. <40 1/3 initial dose given daily or initial dose every 3 days. Intravenous Renal impairment: Dose adjustment may be required.
Contraindication
Hypersensitivity.
Mode of Action
Glycopeptide antibiotic with spectrum of activity is similar to vancomycin but teicoplanin may be more active in vitro against enterococci and some anaerobic organisms but some coagulase-negative Staphylococci are less sensitive to teicoplanin than to vancomycin.
Precaution
Preexisting renal insufficiency, hypersensitivity to vancomycin. Perform periodic haematological studies, renal, LFT. Pregnancy, lactation.
Side Effect
Fever, chills, allergic reactions, GI disturbances, headache, dizziness, "red-man" syndrome, disturbances in liver enzymes, renal impairment, ototoxicity, blood dyscrasias. Pain, erythema, thrombophloebitis, abscess at site of admin. Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.
Interaction
Other nephrotoxic and/or neurotoxic drugs.
