Antigrain0.5mg
Type:10 Tablets
Generic Name:Pizotifen
Manufacturer:The Ibn Sina Pharmaceutical Ind. Ltd.
Price:৳32.50
Indication
Headache, Migraine
Administration
May be taken with or without food.
Adult Dose
Oral Prophylaxis of migraine; Prophylaxis of cluster headache Adult: Initially, 0.5 mg, increase gradually as necessary. Maintenance: 1.5 mg daily as a single dose at night or in 3 divided doses. Max: 4.5 mg daily (max ?3 mg/dose). Hepatic impairment: Dose adjustment may be needed.
Child Dose
Oral Prophylaxis of migraine; Prophylaxis of cluster headache Child: >2 yr Initially, 0.5 mg. May increase gradually up to 1.5 mg daily in divided doses (max 1 mg/dose).
Renal Dose
Renal impairment: Dose adjustment may be needed.
Contraindication
Premature infants or neonates. Postural giddiness.
Mode of Action
Pizotifen is a sedating antihistamine with strong serotonin antagonist and weak antimuscarinic properties. It also antagonises the action of tryptamine.
Precaution
Patient w/ angle-closure glaucoma, urinary retention, epilepsy. Avoid abrupt withdrawal. Renal and hepatic impairment. Childn. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness, somnolence and dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor hepatic function (prolonged use), wt gain, BP.
Side Effect
Increased appetite, nausea, wt gain, drowsiness, dizziness, dry mouth, fatigue, muscle pain or cramps, heavy or restless legs, fluid retention, facial flushing, reduced libido, exacerbation of epilepsy, dreaming, hepatic injury.
Interaction
Enhances sedative effects of CNS depressants. Additive antimuscarinic action with other antimuscarinic drugs. May mask warning signs of damage caused by ototoxic drugs eg, aminoglycosides.
