Pza Ciba500mg
Type:Tablet
Generic Name:Pyrazinamide
Manufacturer:Novartis (Bangladesh) Ltd.
Price:৳2.35
Indication
Tuberculosis
Administration
Should be taken with food.
Adult Dose
Oral Tuberculosis Adult: As part of a multidrug regimen: For standard unsupervised 2-mth treatment: <50 kg: 1.5 g daily; >50 kg: 2 g daily. For intermittent supervised 2-mth treatment: <50 kg: 2 g 3 times wkly; >50 kg: 2.5 g 3 times wkly. Hepatic impairment: Severe: Contraindicated.
Child Dose
Oral Tuberculosis Child: As part of a multidrug regimen: For standard unsupervised 2-mth treatment: 35 mg/kg daily. For intermittent supervised 2-mth treatment: 50 mg/kg 3 times wkly.
Renal Dose
Renal impairment: May need dose reduction.
Contraindication
Hypersensitivity; existing liver disease; acute gout or hyperuricaemia. Porphyria. Pregnancy and lactation.
Mode of Action
Pyrazinamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of the infection and the susceptibility of the infecting organism. Its activity appears to partly depend on conversion of the drug to pyrazinoic acid (POA), which lowers the pH of the environment below that which is necessary for growth of Mycobacterium tuberculosis. Susceptible strains of M. tuberculosis produce pyrazinamidase, an enzyme that deaminates pyrazinamide to POA, and the in vitro susceptibility of a given strain of the organism appears to correspond to its pyrazinamidase activity.
Precaution
Patient w/ DM, history of gout. Mild to moderate hepatic and renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor liver function, serum uric acid, sputum culture; chest x-ray 2-3 mth into treatment and at completion.
Side Effect
1-10% Malaise,Nausea,Vomiting,Anorexia,Arthralgia,Myalgia <1% Fever,Rash,Itching,Acne,Photosensitivity,Gout,Dysuria,Porphyria,Thrombocytopenia,Hepatotoxicity,Interstitial nephritis Potentially Fatal: Severe liver damage, fulminant hepatitis.
Interaction
Antagonises the effect of uricosuric agents (e.g. probenecid, sulfinpyrazone). May reduce the contraceptive effect of oestrogens. May inactivate oral typhoid vaccine. May increase the serum concentration of ciclosporin. May enhance the hepatotoxic effect of rifampicin.