Hytrain1mg
Type:Tablet
Generic Name:Terazosin
Manufacturer:Unimed Unihealth Pharmaceuticals Ltd.
Price:৳12.54
Indication
Hypertension, Benign prostatic hyperplasia
Administration
May be taken with or without food. Give first dose and subsequent increases at bedtime to avoid syncope
Adult Dose
Oral Hypertension Adult: Initially, 1 mg at bedtime, gradually increased at 7-day intervals according to response. Maintenance: 2-10 mg once daily. Max: 20 mg/day in 1 or 2 divided doses. Elderly: Initial: 0.5 mg at bed time and titrate to response Benign prostatic hyperplasia Adult: Initially, 1 mg at bedtime gradually increased at 7-day intervals according to response. Maintenance: 5-10 mg once daily. Hepatic impairment: Use with caution
Contraindication
Hypersensitivity to quinazoline derivatives.
Mode of Action
Terazosin is an alpha1-adrenoceptor antagonist which blocks peripheral postsynaptic receptors resulting to decreased arterial tone. It relaxes smooth muscle of the bladder neck causing a reduction of bladder outlet obstruction.
Precaution
Prostate cancer should be ruled out before starting therapy. Patient w/ history of micturition syncope, prostate cancer, angina. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive, operate machinery or engage in hazardous activities. Monitoring Parameters Monitor BP regularly. Lactation: Not known if excreted into breast milk; use caution
Side Effect
>10% Dizziness (10-20%),Asthenia (2-13%) 1-10% Hypotension (3-7%),Rhinitis/nasal congestion (2-6%),Lightheadedness (3-5%),Somnolence (3-5%),Palpitation (4%),Nausea (2-4%),Edema (3%),Sinusitis (3%),Dyspnea (2-3%),Fatigue (2.5%),Headache (2.5%),Back pain (2.4%),Flulike syndrome (2.4%),Tachycardia (2%),Amblyopia (1-2%),Blurred vision (1-2%),Impotence (1-2%),Syncope (1%)
Interaction
Concomitant admin w/ phosphodiesterase-5 (PDE-5) inhibitors (e.g. sildenafil) can result in additive BP lowering effects and symptomatic hypotension. Possible significant hypotension when admin w/ other antihypertensive agents e.g. verapamil.
