Valcox10mg
Type:Tablet
Generic Name:Valdecoxib
Manufacturer:Opsonin Pharma Limited
Price:৳3.00
Indication
Osteoarthritis, Rheumatoid arthritis, Dysmenorrhoea
Administration
May be taken with or without food.
Adult Dose
Oral Osteoarthritis, Rheumatoid arthritis Adult: 10 mg once daily. Dysmenorrhoea Adult: 20 mg bid. Hepatic Impairment Child-Pugh scale 7-9: Initiate with caution. Child-Pugh scale >10: Avoid.
Renal Dose
Renal Impairment CrCl Dosage <30 Initiate with caution.
Contraindication
Hypersensitivity to sulfonamides, NSAIDs and other COX 2 inhibitors; asthma, urticaria; severe hepatic impairment; pregnancy (third trimester); lactation. Active GI bleed or ulceration, severe CHF, inflammatory bowel disease.
Mode of Action
Valdecoxib acts by selectively inhibiting prostaglandin synthesis primarily by blocking cyclooxygenase (COX-2) enzyme. It was withdrawn worldwide, following risk of serious skin reactions and cardiovascular side effects.
Precaution
Mild to moderate hepatic impairment; history of ulcer disease or GI bleeding; dehydration, hypertension, history of heart failure, left ventricular dysfunction, pre-existing oedema. Monitor Hb or haematocrit values for signs and symptoms of anaemia.
Side Effect
Hypertension, back pain, myalgia, peripheral oedema, influenza-like symptoms, dizziness, headache, abdominal fullness, abdominal pain, diarrhoea, dyspepsia, flatulence, nausea, myalgia, sinusitis. Potentially Fatal: Toxic epidermal necrolysis, exfoliative dermatitis.
Interaction
Concomitant admin of aspirin may result in an increased risk of GI ulceration and complications. It decreases the antihypertensive effect of antihypertensives e.g. ACE inhibitors. It increases plasma conc of dextromethorphan. It significantly decreases lithium serum clearance and renal clearance.