Stopain25mg
Type:Tablet
Generic Name:Pentazocine Hydrochloride
Manufacturer:Beximco Pharmaceuticals Ltd.
Price:৳5.00
Indication
Moderate to severe pain
Administration
Should be taken with food. Take after meals.
Adult Dose
Oral Moderate to severe pain Adult: 50-100 mg every 3-4 hrs; max 600 mg daily. Hepatic impairment: Reduce dose or avoid in liver disease.
Child Dose
Oral Moderate to severe pain Child: 6-12 yr: 25 mg every 3-4 hr.
Renal Dose
Renal impairment: CrCl (ml/min) Dosage Recommendation 10-50 75% normal dose. <10 50% normal dose.
Contraindication
Head injury; narcotic dependence; respiratory depression; raised intracranial pressure; MI; heart failure; arterial or pulmonary hypertension; porphyria; pregnancy (prolonged use or high doses at term).
Mode of Action
Pentazocine is a benzomorphan derivative with mixed opioid agonist and antagonist actions. It alters perception of and response to pain and produces generalised CNS depression by binding to opiate receptors in the CNS and acting as a partial agonist/antagonist.
Precaution
May precipitate withdrawal in narcotic addicts. Impaired respiratory, renal and hepatic function; morbidly obese patients; thyroid dysfunction; prostatic hyperplasia or urinary stricture; biliary tract impairment; adrenal insufficiency (including Addison's disease); abdominal conditions. Elderly or debilitated patients; seizure-prone patients; children and infants (safety and efficacy not established in <1 yr); lactation. May impair ability to drive or operate machinery. Administer IM rather than SC (when frequent inj are needed) and inj sites should be varied. Lactation: unknown if excreted in breast milk, use caution
Side Effect
Physical dependence; sedation, dizziness, euphoria, lightheadedness, alterations of mood; respiratory depression; visual hallucinations, disorientation, confusion; hypertension, tachycardia, circulatory depression; shock; hypotension; nausea, vomiting, constipation; seizures, diaphoresis; rash; blood dyscrasias; local tissue damages (SC), muscle fibrosis (IM). Potentially Fatal: Respiratory depression, hypotension, circulatory failure, deepening coma, convulsions.
Pregnancy Category Note
Pregnancy Category: C; D if used for prolonged periods or near term
Interaction
Depressant affects potentiated by alcohol, CNS depressants; concurrent use with fluoxetine may lead to diaphoresis, ataxia flushing and tremor associated with serotonin syndrome.
