Secnid500mg/10ml
Type:10ml bot
Generic Name:Secnidazole
Manufacturer:Square Pharmaceuticals PLC.
Price:৳25.17
Indication
Giardiasis, Amoebiasis, Trichomoniasis
Adult Dose
Oral Trichomoniasis; Amoebiasis; Giardiasis Adult: 2 g as a single dose. Severe invasive amoebiasis Adult: 1.5 g daily as single or in divided doses for 5 days.
Child Dose
Oral Trichomoniasis; Amoebiasis; Giardiasis Child: 30 mg/kg as a single dose. Severe invasive amoebiasis Child: 30 mg/kg daily for 5 days.
Contraindication
Hypersensitivity; pregnancy (1st trimester) and lactation.
Mode of Action
Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage.
Precaution
Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders.
Side Effect
Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances.
Interaction
Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life. Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage.
