Santinal MR 200200mg
Type:M R Capsule
Generic Name:Dipyridamole
Manufacturer:Unimed Unihealth Pharmaceuticals Ltd.
Price:৳10.00
Indication
Stroke, Thromboembolism, Transient ischaemic attack
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before meals. May be taken w/ meals to reduce GI discomfort.
Adult Dose
Oral Thromboembolism Prophylaxis Post-Cardiac Valve Replacement Adult: 75-100 mg PO q6hr as adjunct to warfarin
Child Dose
Oral Thromboembolism Prophylaxis Post-Cardiac Valve Replacement Child: 3-6 mg/kg/day PO divided q6-8hr
Contraindication
Hypersensitivity. Peptic ulcer.
Mode of Action
Dipyridamole causes an accumulation of adenosine, adenine nucleotides and cAMP by inhibiting the activity of adenosine deaminase and phosphodiesterase thus inhibiting platelet aggregation and may cause vasodilation.
Precaution
In patients with rapidly worsening angina, subvalvular aortic stenosis, haemodynamic instability associated with recent MI or coagulation disorders esp when given IV during myocardial imaging. Hypotension, unstable angina, aortic stenosis. Pregnancy and lactation. Safety and efficacy are not established in childn < 12 yrs. Lactation: enters breast milk; use with caution
Side Effect
>10% Chest pain (20%),Abnormal ECG (15.9%),Dizziness (12%) 1-10% ST-T changes (7.5%),Abdominal discomfort, oral (6.1%),Extrasystole (5%),Flushing (3.4%),Generalized pain (2.6%),Headache, oral (2.3%) Frequency Not Defined Myocardial infarction (rare),Ventricular arrhythmia (rare),Bronchospasm (rare),Dyspnea
Pregnancy Category Note
Pregnancy Category: B Lactation: enters breast milk; use with caution
Interaction
Aminophylline may reverse vasodilatation effect. Useful combination with aspirin in prevention of thromboembolism. Efficacy reduced by concurrent admin of antacids. Concurrent use may increase the cardiotoxic effects of adenosine. Potentially Fatal: Potentiates effects of oral anticoagulants and antiarrhythmic agents.
