Rythmosin150mg
Type:10 Tablets
Generic Name:Propafenone Hydrochloride
Manufacturer:Unimed Unihealth Pharmaceuticals Ltd.
Price:৳150.00
Indication
Supraventricular and ventricular arrhythmias, Atrial Fibrillation/Flutter
Administration
Should be taken with food. Take after meals. Swallow whole, do not chew/crush.
Adult Dose
Oral Supraventricular and ventricular arrhythmias, Atrial Fibrillation/Flutter Adult: For immediate-release tablet: Usual initial doses: 150 mg tid, may increase at intervals of 3-4 days up to 300 mg tid. Dose reduction is recommended in patients weighing <70 kg. Elderly: Dose reduction is recommended. Hepatic impairment: Dose reduction is recommended.
Child Dose
Safety and efficacy not established
Contraindication
Uncontrolled heart failure, marked hypotension, severe bradycardia and heart block, conduction abnormalities, cardiogenic shock, myasthenia gravis.
Mode of Action
Propafenone is a class 1C antiarrhythmic drug with local anaesthetic effects, and a direct stabilising action on myocardial membranes. The electrophysiological effect manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity.
Precaution
Severe pulmonary obstructive diseases, CHF, cardiac pacemaker, impaired renal/hepatic function, pregnancy, lactation, elderly. Correct electrolyte disturbances before starting treatment. May worsen heart failure in patients with preexisting organic heart disease. May worsen or cause new severe ventricular arrhythmias e.g. ventricular tachycardia or fibrillation. May aggravate electrically induced ventricular tachycardia in some patients. Lactation: Crosses into breast milk; discontinue drug or do not nurse
Side Effect
>10% Unusual taste (7-23%),Dizziness/lightheadedness (7-15%),N/V (3-11%) 1-10% Constipation (4-8%),Headache (2-6%),Intraventricular conduction delay (4%),Fatigue (6%),Blurred vision (3%),Weakness (3%),Dyspnea (2%),Wild complex tachycardia (2%),Bradycardia (2%),Palpitations (2%),Tremor (2%),Anorexia (2%),Diarrhea (2%),Ataxia (2%),1°AV block (2-5%),Angina (5%),Palpitations (3%),CHF (2-3% ),Chest pain (2%),Bradyarrhythmia (2%),AF (1%),Bundle branch block (1%),2nd degree AV block (1%),Hypotension (1%),Sinus arrest (1%) Frequency Not Defined Lethargy,Rash,Dyspepsia,Dry mouth,Agranulocytosis,Hepatotoxicity (rare),Systemic lupus erythematosus (rare),Bronchospasm (rare) Potentially Fatal: SA/AV or intraventricular blocks. Severe hypotension, especially in elderly.
Interaction
Effect may be potentiated by local anesth, beta-blockers, TCA. May increase plasma level of propranolol, metoprolol, desipramine, cyclosporin, digoxin, theophylline. Plasma conc may rise when taken simultaneously w/ cimetidine or quinidine. May enhance effect of anticoagulant. Simultaneous administration w/ phenobarb or rifamycin may decrease propafenone plasma conc, possibly in sub-therapeutic levels.