Rotomycin300mg
Type:Tablet
Generic Name:Roxithromycin
Manufacturer:Kemiko Pharmaceuticals Ltd.
Price:৳14.04
Indication
Pneumonia, Pharyngitis, Susceptible infections, Sinusitis, Otitis media, Cellulitis,Tonsillitis, Folliculitis, Carbuncles, Prostatitis, Urethritis, Acute and chronic bronchitis, Bronchopneumonia, Furuncles, Pyoderma, Impetigo and infected dermatitis, Cervicitis and salpingitis
Administration
Should be taken on an empty stomach. Take at least 15 min before meals.
Adult Dose
Oral Susceptible infections Adult: 150 mg bid or 300 mg once daily for 5-10 days in susceptible infections. Hepatic impairment: Usual daily doses should be halved in hepatic impairment.
Child Dose
Oral Susceptible infections Child: 6-40 kg: 5-8 mg/kg daily.
Renal Dose
Renal impairment: Dosage adjustment may be required.
Contraindication
Hypersensitivity. Porphyria.
Mode of Action
Roxithromycin inhibits protein synthesis by irreversibly binding to the 50s ribosomal subunits thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.
Precaution
Hepatic impairment. Monitor liver function. Prolonged treatment increases risk of hepatotoxicity. History of arrhythmias.
Side Effect
Nausea, vomiting, abdominal pain, diarrhoea, weakness, malaise, anorexia, constipation, dyspepsia, flatulence; hepatitis; rashes, headache, dizziness, weakness, changes in blood counts; increased liver enzyme values; eosinophilia; rarely, acute pancreatitis.
Interaction
May raise serum levels of ciclosporin and digoxin. Increased risk of rhabdomyolysis when used with simvastatin.
