Medicase - Reset 1g - 100ml bot - 10mg/ml

Reset 1g10mg/ml

Type:100ml bot

Generic Name:Paracetamol IV

Manufacturer:Incepta Pharmaceuticals Ltd.

Price:৳120.00

Indication

Mild to moderate pain and high fever

Administration

The paracetamol solution is administered as a 15-minutes intravenous infusion. Paracetamol solution for infusion can be diluted in a 0.9% Sodium Chloride or 5% Glucose solution up to one tenth. In this case, use the diluted solution within the hour following its preparation (infusion time included).

Adult Dose

Intravenous Mild to moderate pain and fever Adult >50 kg: 1g up to 4 times a day. Max: 4 g daily. Admin by infusion over 15 min. Adult 33 to 50 kg: 15 mg/kg body wt, up to 4 times a day. Max: 60 mg/kg (up to 3 g) daily

Child Dose

Intravenous Mild to moderate pain and fever Child >12 years, >50 kg: 1g up to 4 times a day. Max: 4 g daily. Admin by infusion over 15 min. Child 2-12 years: upto 33kg: 15 mg/kg body wt, up to 4 times a day. Max: 75 mg/kg daily. Children: <10 kg: 7.5 mg/kg body wt, up to 4 times a day.

Contraindication

Paracetamol is contraindicated in patients with severe renal impairment and hepatic disease (Viral Hepatitis). Known hypersensitivity to paracetamol.

Mode of Action

Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.

Precaution

Hepatocelluar insufficiency. Severe renal insufficiency (creatinine clearance <30 mL/min), Glucose-6-Phosphate Dehyrogenase (G6PD) deficiency, Chronic alcoholism, Anorexia, cachexia, chronic malnutrition, Dehydration, hypovolemia.

Side Effect

Side effects of paracetamol are usually mild, though haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.