Remazin50mg
Type:Tablet
Generic Name:Diethylcarbamazine Citrate
Manufacturer:Reman Drug Laboratories Ltd.
Price:৳0.75
Indication
Filariasis, Lymphatic filariasis, Pulmonary eosinophilia, Loiasis, Toxocariasis
Adult Dose
W. Bancrofti, B Malayi Day 1: 50 mg PO PC Day 2: 50 mg TID Day 3: 100 mg TID Day 4-14: 6 mg/kg/day divided TID Loa Loa Day 1: 50 mg PO PC Day 2: 50 mg TID Day 3: 100 mg TID Day 4-21: 9 mg/kg/day divided TID M. Streptocerca 6 mg/kg PO qDay x14 days Pulmonary Eosinophilia, Tropical Pulmonary eosinophilia, tropical: 6 mg/kg/day divided TID x14 days Larva Migrans, Visceral 6 mg/kg/day divided TID x7-10 days
Child Dose
W. Bancrofti, B Malayi Day 1: 1 mg/kg PO PC Day 2: 1 mg/kg PO TID Day 3: 1-2 mg/kg PO TID Day 4-14: 6 mg/kg/day divided TID Loa Loa Day 1: 1 mg/kg PO PC Day 2: 1 mg/kg PO TID Day 3: 1-2 mg/kg PO TID Day 4-21: 9 mg/kg/day divided TID Pulmonary Eosinophilia, Tropical Pulmonary eosinophilia, tropical: 6 mg/kg/day divided TID x14 days Larva Migrans, Visceral 6 mg/kg/day divided TID x7-10 days
Contraindication
Pregnancy, hypersensitivity; lactation; infants, elderly or debilitated patients; impaired renal function; cardiac disease.
Mode of Action
Diethylcarbamazine is an anthelmintic that is used in the treatment of lymphatic filariasis. It is active against the microfilariae and adult worms of W. bancrofti, B. malayi, B. timori and Loa loa but only against the microfilariae of O. volvulus. It is also used in treatment of toxocariasis. Repeated courses may be necessary.
Precaution
Patients with poor health. Lactation: not known if excreted in breast milk
Side Effect
Fever, headache, vomiting, dizziness, drowsiness, nausea, chills. Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage.
Pregnancy Category Note
Pregnancy Category: X Lactation: not known if excreted in breast milk