Proscan250mg
Type:10 Tablets
Generic Name:Flutamide
Manufacturer:Renata Limited
Price:৳120.00
Indication
Prostate cancer
Administration
May be taken with or without food.
Adult Dose
Oral Palliative treatment of prostatic carcinoma Adult: 250 mg tid preferably at least 3 days before gonadorelin analogue treatment.
Contraindication
Hypersensitivity, severe hepatic impairment, pregnancy and lactation.
Mode of Action
Flutamide is a nonsteroidal 'pure' antiandrogen which acts directly on the target tissues either by blocking androgen uptake or by inhibiting cytoplasmic and nuclear binding of androgen.
Precaution
Perform liver function tests before starting treatment and at regular intervals. Treatment is not recommended in patients whose ALT values exceed twice the upper limit of normal. Regular assessment of prostate specific antigen level may help to monitor disease progression. Advise patient against discontinuing drug on their own. Exercise caution in patients with cardiac disease. Lactation: Excretion in milk unknown; not recommended
Side Effect
>10% Hot flashes (61%),Decreased libido (36%),Impotence (31%),Diarrhea (12%),Nausea/vomiting (11%) 1-10% Gynecomastia (9%),Anorexia (4%),Edema (4%),Leukopenia (3%),Rash (3%) Frequency Not Defined Hemolytic anemia, methemoglobinemia Increased AST, ALT, bilirubin, BUN
Pregnancy Category Note
Pregnancy Category: D Lactation: Excretion in milk unknown; not recommended
Interaction
Increased prothrombin time in patients on long-term warfarin treatment.
