No Spa40mg/2ml
Type:Injection
Generic Name:Drotaverine Hydrochloride
Manufacturer:Ambee Pharmaceuticals Ltd.
Price:৳7.98
Indication
Gastrointestinal tract spasm, Irritable bowel syndrome, Dysmenorrhea, Biliary colics, Renal colics
Administration
May be taken with or without food.
Adult Dose
Oral As an antispasmodic Adult: 1 to 2 tablets, 3 times daily. Injection: Adults: 1 to 2 ampoules, intramuscularly or subcutaneously, 1-3 times daily. For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection.
Child Dose
Oral As an antispasmodic Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily. 40 mg 1-2 times daily Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily. 20 mg 1-2 times daily
Contraindication
Severe renal/hepatic/cardiac dysfunction. Porphyria.
Mode of Action
Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.
Precaution
Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.
Side Effect
Vertigo, nausea, vomiting, dry mouth.
Interaction
May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.
