Mastel 1010mg
Type:10 Tablets
Generic Name:Mizolastine
Manufacturer:ACI Limited
Price:৳70.00
Indication
Allergic conditions
Adult Dose
Oral Allergic conditions Adult: 10 mg daily. Elderly: 10 mg daily.
Child Dose
Oral Allergic conditions Child: >12 yr: 10 mg daily.
Contraindication
Significant cardiac or hepatic disease; electrolyte imbalance, particularly hypokalaemia; known or suspected QT prolongation. Clinically significant bradycardia.
Mode of Action
Mizolastine, a non-sedating antihistamine, blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also has mast-cell stabilising properties.
Precaution
May impair ability to drive or operate machinery. Elderly. Pregnancy (avoid in 1st trimester) and lactation.
Side Effect
Dry mouth, diarrhoea, abdominal pain, nausea; transient drowsiness, headache, dizziness; anxiety and depression; raised liver enzymes: low neutrophil count; transient asthenia, increased appetite associated with wt gain; allergic reactions e.g. angioedema, generalised rash/urticaria, pruritus and hypotension; tachycardia, palpitations; vasovagal attack; arthralgia and myalgia. Potentially Fatal: Anaphylaxis.
Interaction
Antidepressants and anxiolytics may enhance sedative effect. Potent inhibitors of or substrates for the hepatic metabolism of mizolastine (e.g. cimetidine, ciclosporin, nifedipine) may alter its metabolism. Potentially Fatal: Increased risk of cardiac arrhythmias with drugs known to prolong the QT interval e.g. class I and III antiarryhthmics. Increased plasma concentrations with macrolide antibiotics and imidazole antifungals.
