l-cardin4mg
Type:Tablet
Generic Name:Lacidipine
Manufacturer:Drug International Ltd.
Price:৳5.05
Indication
Hypertension, Storke prevention
Administration
May be taken with or without food.
Adult Dose
Oral Hypertension Adult: Initially, 2 mg once daily, may increase after 3-4 wk to 4 mg/day. Max: 6 mg/day. Hepatic impairment: Severe: Reduce dose.
Contraindication
Within 1 mth of MI, cardiogenic shock, unstable angina, aortic stenosis.
Mode of Action
Lacidipine is a potent dihydropyridine Ca antagonist mainly selective for Ca channels in the vascular smooth muscle. It dilates peripheral arterioles resulting in reduced peripheral vascular resistance and BP.
Precaution
Conduction abnormalities, congenital or acquired QT prolongation, poor cardiac reserve. Hepatic impairment. Pregnancy and lactation.
Side Effect
Headache, flushing, oedema, dizziness, palpitations, aggravation of angina, increased alkaline phosphatase. Rarely asthenia, rash (e.g. erythema and itching), gastric upset, nausea, gum hyperplasia, polyuria, muscle cramps, mood disturbances.
Interaction
Additive effect w/ diuretics, ACE inhibitors and beta-blockers. May increase plasma level w/ cimetidine. Metabolism may be affected by CYP3A4 inhibitors (e.g. itraconazole) and inducers (e.g. rifampicin). May attenuate antihypertensive effect w/ corticoids or tetracosactid
