Grisofulvin M500mg
Type:Tablet
Generic Name:Griseofulvin
Manufacturer:Modern Pharmaceuticals Ltd.
Price:৳6.94
Indication
Dermatophytosis
Administration
Should be taken with food. Take immediately after meals.
Adult Dose
Oral Dermatophytosis Adult: 0.5-1 g daily in single or divided doses. Treatment duration: 2-8 wk (hair and skin infections); up to 6 mth (fingernail infections); >12 mth (toenail infections).
Child Dose
Oral Dermatophytosis Child: PO 20–25 mg/kg q24h
Contraindication
Severe liver disease; porphyria; monilial infection; SLE; pregnancy.
Mode of Action
Griseofulvin is a fungistatic antibiotic that inhibits fungal cell division at metaphase and binds to human keratin making it resistant to fungal infections. It has activity against common dermatophytes including epidermophyton, Microsporum, or Trichophyton spp.
Precaution
Lactation; may impair ability to drive or operate machinery; avoid exposure to intense sunlight or artificial light. Regular monitoring of the renal, hepatic and blood tests should be done. Lactation: Excretion in milk unknown; avoid use because of potential tumorigenicity
Side Effect
Oral thrush; GI distress, taste perversion; dizziness, confusion, headache, depression, insomnia, fatigue; peripheral neuritis, photosensitivity; skin rashes, urticaria, erythema multiforme; leucopenia, proteinuria. Potentially Fatal: Hepatotoxicity; angioedema.
Interaction
Antagonises oral anticoagulants and oral contraceptives. Decreased GI absorption with phenobarbital. Reduced plasma concentrations with enzyme inducers e.g. phenylbutazone and hypnotics. Potentially Fatal: Enhances effects of alcohol and causes disulfiram-like reaction.