Force 1g IV1gm
Type:IV Injection
Generic Name:Cefpirome
Manufacturer:Square Pharmaceuticals PLC.
Price:৳402.72
Indication
Susceptible infections
Administration
IV Administration Administer by IV inj over 3-5 min, OR By intermittent infusion over 20-30 min
Adult Dose
Intravenous Susceptible infections Adult: As sulfate: 1-2 g every 12 hrly
Renal Dose
Renal impairment: Loading dose: 1-2 g followed by a maintenance dose adjusted according to CrCl. CrCl (ml/min) 20-50 0.5-1 g bid. 5-20 0.5-1 g once daily. <5 (in haemodialysis patients) 0.5 or 1 g once daily with half-dose after each dialysis session.
Contraindication
Hypersensitivity; porphyria.
Mode of Action
Cefpirome binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
Allergy to penicillin or to cephalosporins; renal impairment, monitor renal and haematological status; pregnancy and lactation. Lactation: excreted in breast milk; unsure if safe; do not use
Side Effect
<1% Colitis,Diarrhea,Dyspnea,Headache,Phlebitis,Rash,Vaginitis,Vomiting Potentially Fatal: Pseudomembranous colitis.
Interaction
Reduced clearance with probenecid.