Corangi 1010mg
Type:10 Tablets
Generic Name:Nicorandil
Manufacturer:Unimed Unihealth Pharmaceuticals Ltd.
Price:৳60.00
Indication
Angina pectoris
Administration
May be taken with or without food.
Adult Dose
Oral Angina pectoris Adult: 10 mg bid, increase if necessary. Usual dose: 10-20 mg bid. May use 5 mg bid for patients prone to headache. Max dose: 30 mg bid. Hepatic impairment: Dose reduction may be necessary.
Contraindication
Cardiogenic shock; hypotension; left ventricular failure with low filling pressure; lactation.
Mode of Action
Nicorandil dilates arterioles and large coronary arteries by opening the potassium channels, and stimulates guanylate cyclase causing venous vasodilatation. It therefore reduces preload and afterload, and improves coronary blood flow.
Precaution
Hypovolaemia, low systolic BP, acute pulmonary oedema, pregnancy. May impair ability to drive or operate machinery.
Side Effect
Headache (usually transitory), flushing, dizziness, nausea, vomiting and weakness. Hypotension and reflex tachycardia at high doses.
Interaction
Hypotensive interaction may occur with alcohol, TCAs, antihypertensives and other vasodilators. Potentially Fatal: Enhanced hypotensive effect with sildenafil and other phosphodiesterase type-5 inhibitors.
