Cinazin 1515mg
Type:10 Tablets
Generic Name:Cinnarizine
Manufacturer:The ACME Laboratories Ltd.
Price:৳10.00
Indication
Nausea and vomiting, motion sickness, vertigo, meniere's disease, peripheral vascular diseases, cerebrovascular disorders, vestibular disorders
Administration
Should be taken with food.
Adult Dose
Oral Peripheral vascular disease Adult: 75 mg bid or tid. Motion sickness Adult: 30 mg 2 hr before travel then 15 mg 8 hrly during the journey if necessary. Cerebrovascular disorders Adult: 75 mg once daily. Vertigo and vestibular disorders Adult: 30 mg tid or 75 mg 1-2 times daily.
Child Dose
Oral Motion sickness Child: 5-12 yr 15 mg 2 hr before travel then 7.5 mg 8 hrly during the journey as necessary. Vertigo and vestibular disorders Child: 5-12 yr 15 mg tid.
Contraindication
Proven hypersensitivity to the drug. Parkinson's disease. Childn and neonates.
Mode of Action
Cinnarizine has calcium-channel blocking activity selective for arterial smooth muscle. It also has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischaemia-induced blood viscosity.
Precaution
Hypotension; pregnancy; lactation; elderly. May impair ability to drive or operate machineries.
Side Effect
Extrapyramidal symptoms sometimes associated with severe depression. Drowsiness, headache, GI upsets, unsteadiness, headache; rarely skin and hypersensitivity reactions, dry mouth, blurred vision, urinary difficulty or retention, constipation and increased gastric reflux, fatigue. Hypolipidaemic effect.
Interaction
CNS depressant effect enhanced with alcohol. Action potentiated by domperidone. Increased sedative effect w/ CNS depressants or TCAs.
