Ceftor 200200mg
Type:4 Tablets
Generic Name:Cefditoren
Manufacturer:Sanofi Bangladesh Ltd.
Price:৳600.00
Indication
Pharyngitis, Community-acquired pneumonia, Susceptible infections, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis
Administration
Should be taken with food.
Adult Dose
Oral Community-acquired pneumonia Adult: 400 mg bid for 14 days. Acute bacterial exacerbation of chronic bronchitis Adult: 400 mg bid for 10 days. Pharyngitis ; Tonsillitis; Uncomplicated skin and skin structure infections Adult: 200 mg bid for 10 days.
Child Dose
<12 years old: Safety & efficacy not established >12 years old: As in adults
Renal Dose
Renal impairment: CrCl (ml/min) 30-49 Maximum: 200 mg bid <30 Maximum: 200 mg once daily
Contraindication
Hypersensitivity to Cefditoren, other cephalosporins; or milk proteins. Carnitine deficiency.
Mode of Action
Cefditoren is a third generation cephalosporin used for treatment of susceptible infections caused by gram-positive and gram-negative bacteria. It inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).
Precaution
Pregnancy and lactation. Patients with penicillin allergy. Avoid prolonged use as pivalate-containing compounds may cause carnitine deficiency over time; greater risk of carnitine deficiency in patients with renal impairment or decreased muscle mass. May decrease prothrombin activity especially in patients with renal or hepatic impairment, poor nutritional status, prolonged antibiotic treatment or patients previously stabilised on anticoagulant therapy. Long term use may result in development of drug-resistant bacteria, or superinfection including Clostridium difficile-associated diarrhoea and pseudomembranous colitis. Lactation: excretion in milk unknown; use with caution
Side Effect
>10% Diarrhea (11-15%) 1-10% Nausea (4-6%),Headache (2-3%),Abdominal pain (2%),Dyspepsia (1-2%),Vomiting (1%) <1% Bacterial/fungal superinfection,C. difficile colitis,Hypersensitivity,Increased bleeding time,Stevens-Johnson syndrome,Vaginal moniliasis Potentially Fatal: Hypersensitivity, anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Pregnancy Category Note
Pregnancy Category: B Lactation: excretion in milk unknown; use with caution
Interaction
Reduced oral bioavailability when coadministered with antacids or H2-receptor antagonists. Probenecid may increase plasma concentration and prolong half-life of Cefditoren. May enhance anticoagulant effect of vitamin K antagonists (e.g. warfarin).
