Cefopen INJ 2 GM2gm/vial
Type:2gm vial
Generic Name:Cefoperazone
Manufacturer:Square Pharmaceuticals PLC.
Price:৳400.00
Indication
Respiratory Tract Infections, Peritonitis and Other Intra-abdominal Infections, Bacterial Septicemia, Infections of the Skin and Skin Structures, Pelvic Inflammatory Disease, Endometritis, and Other Infections of the Female Genital Tract, Urinary Tract Infections
Adult Dose
Parenteral Susceptible infections Adult: As sodium: 2-4 g daily in 2 divided doses, increased to 12 g daily in 2-4 divided doses for severe infections given as deep IM or IV infusion. Hepatic impairment: Max for hepatic impairment or biliary obstruction: 4 g daily. W/ renal impairment: 1-2 g daily.
Renal Dose
Renal impairment: W/ hepatic impairment: 1-2 g daily.
Contraindication
Hypersensitivity to cephalosporin.
Mode of Action
Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
History of penicillin allergy; renal or hepatic impairment; pregnancy, lactation; cystic fibrosis.
Side Effect
Skin rash, urticaria; eosinophilia, diarrhoea, nausea, vomiting; phloebitis; hypoprothrombinaemia; superinfection. Potentially Fatal: Neuromuscular hypersensitivity; nephrotoxicity.
Interaction
Disulfiram-like reaction with alcohol. Potentiates anticoagulants. Potentially Fatal: Enhances nephrotoxicity by aminoglycosides and furosemide.
