Arduan4mg/2ml
Type:Injection
Generic Name:Pipecuronium bromide
Manufacturer:
Price:৳136.00
Indication
Muscle relaxant in general anaesthesia, Facilitate endotracheal intubation
Adult Dose
Intravenous Muscle relaxant in general anaesthesia; Facilitate endotracheal intubation Adult: Initial dose: 80-100 mcg/kg. Subsequent doses: 10-20 mcg/kg. Initial dose following suxamethonium admin or in patients at high risk: 50-60 mcg/kg. Initial dose for caesarean section: 35 mcg/kg.
Contraindication
Hypersensitivity.
Mode of Action
Pipecuronium bromide is an aminosteroidal competitive neuromuscular blocker. It does not have significant CV adverse effects or histamine-related effects.
Precaution
Pulmonary disease, respiratory insufficiency, asthma, neuromuscular disease, dehydration, severely ill patients, hepatic or renal impairment. Doses in obese patients should be based on patient's ideal body weight. Pregnancy, lactation.
Side Effect
Transient hypotension, bradycardia, reduced cardiac output. Potentially Fatal: Anaphylactic reactions and malignant hyperthermia.
Interaction
Actions antagonised by cholinesterases and long term carbamazepine, phenytoin or corticosteroids usage. Enhanced block when used with drugs that have neuromuscular blocking activity such as lidocaine, quinidine, verapamil and aminoglycosides. Potentially Fatal: Effects enhanced by volatile inhalational anaesthetics, ketamine (IV), antiarrhythmics, antibacterials, K depleting diuretics, parenteral Mg salts.