Indication
Postmenopausal osteoporosis, Metastatic breast cancer, Anaemia of chronic renal failure, Anaemia in chemotherapy patients
Adult Dose
Intramuscular As anabolic after debilitating illness; Postmenopausal osteoporosis; Metastatic breast cancer Adult: As decanoate: 25-100 mg once every 3-4 wk. Anaemia of chronic renal failure Adult: As decanoate: 50-200 mg wkly. Anaemia in chemotherapy patients Adult: 50-150 mg wkly.
Contraindication
Prostatic or breast carcinoma (male); nephrosis, porphyria; infants, pregnancy and lactation.
Mode of Action
Nandrolone is an anabolic steroid. It promotes tissue-building processes and protein anabolism. It also stimulates erythropoeitin production, causing an increase in haemoglobin and RBC volume.
Precaution
Monitor diabetic patients carefully. Conditions influenced by oedema (e.g. CV disease, migraine, seizure disorder, renal impairment). Hepatic impairment. Elderly. Discontinue if signs of virilisation in women occur. Monitor skeletal maturation in children.
Side Effect
Male: Postpubertal: Acne, gynaecomastia, bladder irritability, priapism, insomnia, chills, decreased libido, hepatic dysfunction, nausea, diarrhoea, prostatic hyperplasia. Prepubertal: Acne, virilism, chills, insomnia, hyperpigmentation, diarrhoea, nausea. Female: Virilism, hypercalcaemia, nausea, diarrhoea, chills, insomnia, iron deficiency anaemia, hepatic dysfunction.
Interaction
May increase effects of oral anticoagulants, insulin, oral antidiabetic agents, adrenal steroid, adrenocorticotropic hormone (ACTH).




