Aldocort0.10mg
Type:10 Tablets
Generic Name:Fludrocortisone Acetate
Manufacturer:Incepta Pharmaceuticals Ltd.
Price:৳100.00
Indication
Primary and secondary adrenocortical insufficiency in Addison disease, Salt-Losing Forms of Congenital Adrenogenital Syndrome
Adult Dose
Oral Adult: Primary adrenocortical insufficiency Adrenocortical Insufficiency/Addison Disease Primary and secondary adrenocortical insufficiency in Addison disease Usual, 0.1 mg/day PO; range, 0.1 mg PO 3 times weekly to 0.2 mg/day PO If hypertension occurs: 0.05 mg/day PO Salt-Losing Forms of Congenital Adrenogenital Syndrome 0.1-0.2 mg/day PO
Child Dose
Not FDA-approved for use in children
Contraindication
Hypersensitivity. Hyperalbuminaemia; hypertension, systemic fungal infections.
Mode of Action
Potent mineralocorticoid with high glucocorticoid activity; Fludrocortisone promotes increased reabsorption of sodium and excretion of potassium from renal distal tubules
Precaution
Use with caution in diabetes mellitus, hypertension, hypothyroidism, electrolyte abnormalities, sodium and water retention, infections, immunizations, ocular herpes simplex, myasthenia gravis, peptic ulcer disease, psychosis, renal insufficiency. Prolonged corticosteroid use may result in elevated intraocular pressure, glaucoma, or cataracts and has been associated with development of Kaposi sarcoma Lactation: Unknown whether drug is excreted in milk; use with caution
Side Effect
Acne, hypertension, sodium and water retention, potassium loss, dizziness, itching, skin rash, headache, convulsions, CHF, muscle weakness, hyperglycaemia, HPA and growth suppression, peptic ulcer, cataracts, raised intraocular pressure and reduced visual acuity. Insomnia, Menstrual irregularity, Myopathy, Neuritis, Osteoporosis
Pregnancy Category Note
Pregnancy category: C Lactation: Unknown whether drug is excreted in milk; use with caution
Interaction
May decrease salicylate levels. Anticholinesterase effects are antagonised. Decreased effects with rifampin, barbiturates, hydantoins and phenytoin. Oral contraceptives or ritonavir may increase the plasma concentrations of fludrocortisone. Increased potassium loss with potassium-depleting drugs e.g. thiazides, furosemide or amphotericin B. Increased risk of GI bleeding or ulceration with NSAIDs. May alter efficacy of anticoagulants when used concurrently.